The ”Pitch Perfect” star will take over from Samantha Spiro as Miss Adelaide next month
The show has also announced an extension, with tickets now available until 7 January 2017.
Wilson said: "A lot of people who know me from my more recent film work have no idea how much theatre has influenced my life. I saw my first musical at age 14, a show called 42nd Street, after one of my family's dogs had unsuccessfully auditioned to be in it. It blew me away and I've loved musical theatre ever since.
"Training at the Australian Theatre for Young People gave me the opportunity to perform onstage in eight productions ranging from new Australian musicals to classic plays. I then went on to write and perform in my own productions before being snapped up to do screen work. I am delighted to be making my West End debut in Guys and Dolls and to be playing such an iconic role as Miss Adelaide is truly an honor. Hopefully I crush it….but you'll have to come and see me to find out!"
Wilson told fans this morning via her Twitter feed, tweeting to her 2.4 million followers:
Proud to announce that I will be joining the West End cast of GUYS & DOLLS for 8 weeks only at the Phoenix Theatre, playing Miss Adelaide!
— Rebel Wilson (@RebelWilson) May 24, 2016
She went on to say that she will appear in the show – currently running at the Phoenix Theatre following a transfer from the Savoy – from 28 June to 21 August 2016.
Wilson, who will take over from Samantha Spiro, will join a cast including Nigel Lindsay as Nathan Detroit and Oliver Tompsett as Sky Masterson.
Wilson is known for her work in films such as Pitch Perfect, for which she won an MTV Movie Award for best breakthrough performance, and Bridesmaids.
Guys and Dolls is Frank Loesser, Jo Swerling and Abe Burrows' musical based on the stories and characters of Damon Runyon. It follows the tales of gangsters in New York and the love story between a gambling man and a Salvation Army woman and features songs such as "Luck Be a Lady" and "Sit Down You're Rockin' The Boat".
Guys and Dolls is currently booking at the Phoenix Theatre until 7 January 2017.