1788 – King George III is preparing for the opening of parliament with his devoted wife, Queen Charlotte and their 15 children. Despite the picture of respectability all is not well in the palace; not only has the King lost the colonies but he’s losing his mind. With the smooth running of Government depending on his sanity and the Prince of Wales increasingly impatient to succeed his father, it’s a race against time to get the King fit. The Prime Minister’s only hope is a self-taught doctor with some unorthodox methods for curing dementia.