In preparation, Frost recently had a photoshoot with none other than Boy George in which she got a full Madge makeover - see the picture below to compare and contrast with Madonna in her 80s prime.
Like a Virgin catches up with Lesley (Frost) as a 38 year-old stuck in the modern crisis - single, no kids, clock ticking. According to press material, "Zoe Lewis has blended the old and the new material together, in a new musical transformation, with pianist and cabaret singer."
Directed by James Phillips, it runs at the Soho Theatre from 24 May to 9 June (previews from 22 May).
Spot the difference: Madonna vs Sadie Frost (Frost photo taken by Boy George for The Hepatitis C Trust's Get Tested! Campaign)