The role was created in the National Theatre production by Whatsonstage.com and Tony Award winner James Corden. Corden transferred the show to the West End (and subsequently Broadway), with his understudy Owain Arthur taking it to its second West End home the Haymarket, where it continues.
The production will mark Rufus Hound's second London theatre role following his turn in Utopia at Soho Theatre earlier this year.
Hound, 33, is best known for his appearances on TV quizzes including Celebrity Juice, Never Mind the Buzzcocks and 8 Out of 10 Cats. His film credits include forthcoming comedy The Wedding Video.
One Man, Two Guvnors, Richard Bean's 1960s Brighton-set re-working of Goldoni's classic A Servant of Two Masters, won Bean the Best New Comedy prize at this year's Whatsonstage.com Awards and has also been recognised with Critics' Circle and Evening Standard gongs as well as an Olivier Award nomination.