Wolverhampton-born Syal's semi-autobiographical novel was first published in 1996 and was subsequently adapted for film. It centres on nine-year-old Meena, growing up in the only Punjabi family in a Black Country mining village.
According to press material, "Syal's novel is a unique vision of a British childhood in the Seventies, a childhood caught between two cultures, each on the brink of change."
Anita and Me was recently added to the new English Literature GCSE syllabus.
Syal said: "I am so thrilled that Anita and Me is being developed and premiered at the Birmingham Rep, in the West Midlands where I grew up, where the novel is set and whose people and stories had such a huge influence on my childhood."
Roxana Silbert added: "Meera's brilliant novel is a wonderful coming of age story. It's an engaging and funny tale set in a tight knit community about a young girl trying to decide her cultural identity and I look forward immensely to realising it on stage."