The Broadway transfer will open at the Vaudeville Theatre in February 2016
Harry Melling (Angry Brigade, Harry Potter) will lead the West End cast of Broadway hit Hand to God, alongside Olivier-Award winner Janie Dee.
The production, which opens at the Vaudeville Theatre in February 2016, will also star Neil Pearson, Jemima Rooper (Breeders, Blithe Spirit) and Kevin Mains.
Moritz von Stuelpnagel directs the Tony-Award nominated show which received rave reviews during its Broadway run at the Booth Theatre.
Billed as a "hilarious and heartbreaking new comedy", Robert Askins' play centres around shy teenager Jason as his sock puppet Tyrone comes to life and takes on a shocking, foul-mouthed personality.
Hand to God opens at the Vaudeville Theatre on 5 February 2016.