Hampstead Theatre's production of Di and Viv and Rose will transfer to the West End next year.
Amelia Bullmore's comedy about female friendship will run at the Vaudeville Theatre from 22 January 2015.
The play started life in the Hampstead Downstairs in 2012, before moving to the larger Upstairs in January last year, starring Outhwaite alongside Gina McKee and Anna Maxwell Martin.
Anna Mackmin's recent credits include Hedda Gabler, The Real Thing and Dancing at Lughnasa at the Old Vic. She also helmed Bullmore's debut play Mammals, which won the Susan Smith Blackburn Prize.
Di and Viv and Rose is billed as a "hilarious and thoughtful exploration of friendship’s impact on life, and life’s impact on friendship.''
It's designed by Paul Wills with lighting by Oliver Fenwick, sound by Simon Baker and choreography by Scarlett Mackmin.
Tamzin Outhwaite, who is currently appearing in Breeders at the St James Theatre, will play eight weeks of the run, until 28 March, with subsequent casting to be announced.