The production, which runs from 28 October 2014, reunites Holman with director Tim Stark, who previously directed Rafts and Dreams as part of a Holman season at the Manchester Royal Exchange in 2003.
Jonah and Otto, which follows two men over the course of a single day as they discuss themes ranging from love to magic, was first seen at the Royal Exchange in 2008.
This will be the first Holman play to be produced in London since Making Noise Quietly at the Donmar Warehouse in 2012.
It features design by Simon Bejer, lighting by Geraint Pughe and sound by Mark Dunne. Casting is still to be announced.