AO Arena (formerly Manchester Arena)

One Night Only: 27 March 2021

Andre Rieu and His Orchestra - 70 Years Young

One Night Only: 23 April 2021

McFly

One Night Only: 16 May 2021

D-Block Europe

One Night Only: 27 May 2021

Little Mix - The Confetti Tour

Performances begin: 28 May 2021

Diana Ross - Top of the World Tour

One Night Only: 18 June 2021

Aerosmith

One Night Only: 29 June 2021

JLS - Beat Again

Performances begin: 01 July 2021

Diana Ross - Top of the World Tour

One Night Only: 14 July 2021

Snoop Dogg - I Wanna Thank Me

One Night Only: 09 September 2021

Dua Lipa - Future Nostalgia Tour

One Night Only: 16 September 2021

Deep Purple

One Night Only: 02 October 2021

The Weeknd

One Night Only: 24 October 2021

Bon Iver

One Night Only: 27 October 2021

Professor Brian Cox - Horizons

One Night Only: 29 October 2021

Blondie - Against The Odds

One Night Only: 09 November 2021

Steps - What the Future Holds

Performances begin: 11 November 2021

Pete Tong - Pete Tong presents Ibiza Classics

One Night Only: 27 November 2021

James - + The Happy Mondays

One Night Only: 03 December 2021

Gary Barlow - Music Played By Humans - The Tour

One Night Only: 09 December 2021

Michael Ball and Alfie Boe - Together at Christmas

One Night Only: 16 December 2021

Bill Bailey - En Route to Normal

Stand-Up Comedy

One Night Only: 22 December 2021

Strictly Come Dancing - The Live Tour

Dance/Ballet

Performances begin: 29 January 2022

John Bishop - Right Here, Right Now

Stand-Up Comedy

Performances begin: 25 February 2022

Ozzy Osbourne - No More Tours 2

One Night Only: 09 March 2022

Hans Zimmer

One Night Only: 24 March 2022

Queen + Adam Lambert

Performances begin: 30 May 2022

Jason Manford - Like Me

Stand-Up Comedy

One Night Only: 15 October 2022