She joins the previously announced Toby Jones, Zoe Wanamaker and Stephen Mangan in the piece, which is set in a sleepy seaside boarding house.
The production – which will be directed by Ian Rickson – marks the 60th anniversary of the play, which originally opened in Cambridge in 1958, transferring to London later that same year.
Mackie became a household name starring as Bill Potts opposite Peter Capaldi in Doctor Who. Her stage credits include Only Human (Theatre503), Obama-ology (Finborough Theatre) and The Curious Incident of the Dog in the Night-Time (West End).
On being cast, she said: "I'm delighted to be back in the West End working with such a prolific director like Ian Rickson – and an incredible cast – on this rich, dark and enthralling play. I love how Pinter creates characters and I feel very lucky to work on one of his best-known plays."
Tickets are priced from £15 with over 20,000 seats at £30 and under.
The Birthday Party runs from 18 January to 14 April, with previews from 9 January 2018.
- Stephen Mangan
- Harold Pinter
- Zoe Wanamaker
- The Birthday Party
- Harold Pinter Theatre
- Toby Jones
- Ian Rickson
- Pearl Mackie
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